Consider systemic therapy for chronic, refractory or severe cutaneous small-vessel vasculitis

Abstract

Cutaneous small-vessel vasculitis (CSVV) typically presents as symmetrical palpable lesions on the lower extremities. Treatment options for CSVV depend on the severity and chronicity of the disease, presence of systemic involvement and identification of causal factors. Conservative management is recommended for first-episode CSVV, with the removal or treatment of any causes. A number of systemic treatments are used to treat recurrent, chronic or severe disease, despite the lack of clinical evidence.