Abstract
In a new article published in the journal Aging, Borras et al. report that Ras-GRF1 homozigous deletion increases both median and maximum longevity in laboratory mice [1]. The human Ras, superfamily now counts more than 150 different proteins subdivided into five different protein families: Ras, Rho, Rab, Arf and Ran. These protein families regulate many cellular processes [2] including cellular differentiation and proliferation (Ras), cell citoskeleton organization and cell shape (Rho), intracellular protein trafficking (Rab, Arf) and nucleo-citoplasmic transport (Ran).
Highlights
In a new article published in the journal Aging, Borras et al report that Ras-GRF1 homozigous deletion increases both median and maximum longevity in laboratory mice [1]
It is interesting to note that, Ras-GRF1 shows only partial homology to the yeast CDC25 and mammalian and yeast Ras proteins have limited functional homology, both exchange factors are regulated by the PKA serine/threonine kinase [4, 5] suggesting the existence of conserved Ras-dependent signaling networks
Both RasGRFs were first discovered for their ability to exchange the nucleotide bound to Ras proteins [6, 7] but these multidomain proteins can have additional activities
Summary
In a new article published in the journal Aging, Borras et al report that Ras-GRF1 homozigous deletion increases both median and maximum longevity in laboratory mice [1]. It is interesting to note that, Ras-GRF1 (one of the mammalian GEFs) shows only partial homology to the yeast CDC25 (one of the two yeast GEFs) and mammalian and yeast Ras proteins have limited functional homology, both exchange factors are regulated by the PKA serine/threonine kinase [4, 5] suggesting the existence of conserved Ras-dependent signaling networks.
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