Abstract
The demonstration of crossreactive epitopes on the surface of erythrocytes infected with multiple strains of Plasmodium falciparum has raised new hopes for the development of an antimalaria vaccine [Gaiman, B. et al. (2001) Proc. Natl. Acad. Sci. USA 98, 2664–2669]. The authors focused on a small, Cys-rich, CD36-binding portion of the variant P. falciparum erythrocyte membrane protein 1 (Pf EMP1). Monoclonal antibodies specific for this portion reacted with multiple P. falciparum strains, which was surprising given the variant nature of the entire Pf EMP1 molecule. The results suggest that immune responses specific for the small, functionally crossreactive portion of Pf EMP1 could be important for immunity against malarial infection. SHK
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
