Abstract
Previously, the RCC1 gene (Regulator of Chromosome Сondensation 1) was characterized, which is considered a regulator of chromosome condensation in the cell cycle. This gene encodes a nuclear protein whose amino acid sequence is highly conserved among all eukaryotes and consists of seven repeating units. We have shown that all the most prominent black bands of polytene chromosomes (about 250) and the chromocenter bind antibodies to this protein. We found that antibodies to the xenopus RCC1 protein specifically bind to the Drosophila and human RCC1 protein, while in Drosophila lines with under replication suppression, the relative amount of the RCC1 protein increases compared to the wild type.
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