Abstract
Normal, non-transformed, mouse cells (N-cells) do not grow as tumors in either normal or immune compromised (ATXFL) mice [1,2]...
Highlights
Normal, non-transformed, mouse cells (N-cells) do not grow as tumors in either normal or immune compromised (ATXFL) mice [1,2]
Consistent with this hypothesis is the fact that when Intermediate cells (I-cells) escape surveillance and grow as tumors in normal mice as well as immune compromised mice (C-cells) they become resistant to natural cytotoxic (NC) activity
When N-cells are transformed to I-cells they become sensitive to mouse TNF⍺ and when I-cells become Cancer cells (C-cells) they are resistant to lysis by mouse TNF⍺
Summary
Non-transformed, mouse cells (N-cells) do not grow as tumors in either normal or immune compromised (ATXFL) mice [1,2]. Cancer cells (C-cells) selected from I-cells in vivo are capable of growth as tumors in both immune compromised and normal mice [1,2]. This establishes a lineage N → I → C. N-cell are not sensitive to lysis by mouse natural cytotoxic (NC) cells [3,4]. Mouse I-cells selected in vivo for growth as tumors in both immune compromised and normal mice (C-cells) are resistant to lysis by mouse natural cytotoxic (NC) cells. Mouse N-cells are not sensitive to lysis mediated by mouse NC cells presumably because they are normal, non-transformed cells. Mouse I-cells, as a result of transformation become sensitive to lysis mediated by mouse NC cells, that is, they become sensitive to immune surveillance
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