Abstract
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α + conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8 + T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3 + DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8 + T cells through XCR1.
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