Consequences of nicotine exposure during different phases of rat brain development

Abstract

Nicotine is a psychoactive drug whose intensity of the addiction is so tremendous that it is now the fastest growing public health hazard in the world. The present study was designed to study the toxic effects of nicotine during different phases of rat brain development. The study is extended through adult brain designated as group A, that received nicotine at the dosage of 5mg/kg of b.wt. for 21days and were sacrificed following 21days of recovery. In the second group P, pups in different gestational phases (P2–P4) were given maternal nicotine exposures for only a period of 7days followed by recovery till they had achieved the age of 40days. A significant decrease in long term memory was observed in adult rats which correlated well with a significant decrease in the acetylcholine esterase activity. Simultaneously a significant decrease in the total glutathione, GSH content and catalase activity was observed which could account for the increase in peroxidation of lipids as evaluated by malondialdehyde (MDA) content in the nicotine exposed adult rats. The consequences of maternal nicotine exposure were different during different exposures regimes the alterations were least during the early gestation period, i.e. P2 (2–9days of their gestation period) as compared to P3 (7–14days of their gestation period) and P4 (21days of their weanling period). The study indicates that the consequences of nicotine exposure are varied during different stages of brain development.