Consequences of in vivo interactions of binary mixtures of salts of metals in alcoholic milieu on the liver and kidney of male albino Westar rats

Abstract

Effects of alcoholic solution of binary mixtures of salts of metals on some hepatic and nephrotic parameters in animal model was monitored using spectrophotometric technique. The serum activities of ALT, AST, ALP and concentrations of ALB, TP, UR, CR were assayed. Animals were orally exposed to the solutions continually for seven, fourteen and twenty one consecutive days respectively. Results obtained showed increased activities of ALT particularly for groups fed Fe+Zn and Pb+Fe relative control (P<0.01) whereas Fe+Cd was least; for AST activity, Pb+Cd caused highest increase in activity with Fe+Zn being the least; trend for ALP activity was Pb+Cd highest while Fe+Zn caused the least effect. In the case of albumin, Fe+Cd highest whereas Fe+Zn and Pb+Cd had values lower than the control group values. In the case of urea, Pb+Cd caused the highest increase whereas Fe+Zn was the least. As for creatinine, Fe+Cd caused the highest increase whereas Fe+Zn had the least (p<0.01). Alcoholic solution of Fe+Zn generally caused marginal increase of the parameters monitored whereas other metals combinations synergistically caused duration of administration- dependent increase levels of the parameters relative control groups and therefore the integrity and functions of the organs could be compromised. InStat3 Statistical Software was used and ANOVA was chosen to analyse the data; P value 0.01 was considered significant.