Abstract
1. 1. The concentrations of serotonin in various brain areas were significantly decreased in the pyridoxine-deficient young rat. 2. 2. There was no change in the concentration of dopamine. 3. 3. Both Bmax and Kd of [ 3H] serotonin binding to membrane preparations from cerebral cortex were increased in deficiency and were restored to normal upon pyridoxine supplementation. 4. 4. There was no change in [ 3H] spiroperidol binding to corpus striatal membrane preparations in pyridoxine-deficient rats.
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