Abstract
Patients granting informed consent for use of what they believe to be an experimental drug tend to respond more actively to the medication, a University of Michigan Medical Center preliminary study suggests. Thomas J. DeKornfeld, MD, told the Federation of American Societies for Experimental biology that the study included 49 patients divided into two groups comparable in age, weight, sex distribution, and type of operative procedure performed. Dr. DeKornfeld is an associate professor in the Department of Anesthesiology. "The only difference (in the two groups) was that members of one group were seen the afternoon before the operation, and permission was requested for use of a new, nonlicensed experimental study drug for pain relief in the postoperative period." These patients, Dr. DeKornfeld said, were told that the new drug appeared to be as safe as most used for pain relief but that no information was available about its analgesic potency.
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