Abstract
Proton therapy is a promising but controversial treatment in the management of prostate cancer. Despite its dosimetric advantages when compared with photon radiation therapy, its increased cost to patients and insurers has raised questions regarding its value. Multiple prospective and retrospective studies have been published documenting the efficacy and safety of proton therapy for patients with localized prostate cancer and for patients requiring adjuvant or salvage pelvic radiation after surgery. The Particle Therapy Co-Operative Group (PTCOG) Genitourinary Subcommittee intends to address current proton therapy indications, advantages, disadvantages, and cost effectiveness. We will also discuss the current landscape of clinical trials. This consensus report can be used to guide clinical practice and research directions.
Highlights
Proton therapy, a type of therapeutic radiation, features charged particles with physical properties that inherently reduce the amount of excess radiation delivered to patients when compared with photon radiation therapy
The authors [3] reported that proton therapy significantly reduced all rectal volumes receiving doses between 10 and 80 Gy (V10 to V80 GyRBE) when compared with intensity-modulated radiation therapy (IMRT) among patients treated for prostate cancer
Trofimov et al [2] showed that proton therapy reduced the maximum dose and the volume receiving more than 110% of the maximum dose when compared with IMRT among patients treated for prostate cancer
Summary
MD5; Huan Giap, MD, PhD6; Jerry D. MD7; Neha Vapiwala, MD8; William Barrett, MD9; Akash Nanda, MD, PhD; Mark V. Mendenhall, MD1; the Genitourinary Subcommittee of the Particle Therapy Co-Operative Group
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