Consensus on the secondary prevention of primary liver cancer

Yuemin Nan ,Zhongping Duan ,Jidong Jia ,Wengang Li ,Yang Ming ,Jian Zhou ,Lai Wei ,Jingfeng Liu ,Junqi Niu ,Rongqi Wang ,Weifeng Zhao ,Suxian Zhao ,Lingdi Liu ,Huiguo Ding ,Yang Yu ,Jia Shang ,Qinmao Fang ,Jin Fan ,Hui Zhang ,Peng Hu ,Yanhang Gao ,Chuanmiao Xie ,Yuguo Zhang ,Xiaoyuan Xu ,Wen Jun Xie

doi:10.1007/s12072-021-10259-7

Abstract

To standardize the effective prevention, surveillance, and diagnosis of primary liver cancer, the Chinese Society of Hepatology, Chinese Medical Association, invited clinical experts and methodologists to develop the Consensus on the Secondary Prevention of Primary Liver Cancer, which was based on the clinical and scientific advances on hepatocellular carcinoma. The purpose is to provide a current basis for the prevention, surveillance, and early diagnosis of primary liver cancer in patients with chronic liver diseases.

Highlights

The purpose of stratified prevention and surveillance of primary liver cancer is to identify and eliminate the risk factors that promote the progression of chronic liver disease
The following classification concept is adopted in the Consensus: primary prevention focuses on preventing initial harm to the general population from the risk factors; secondary prevention is to control the relevant causes and risk factors, and carry out risk-stratified surveillance in the population with chronic liver disease, thereby reducing or delaying the occurrence of hepatocellular carcinoma (HCC); tertiary prevention is to further reduce HCC recurrence and mortality, and improve overall survival after radical treatment (Fig. 1)
Primary liver cancer is a common malignant tumor and a significant cause of cancer deaths, and mainly includes three different pathological types: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and HCC–ICC, which are different in pathogenesis, biological behavior, histological morphology, treatment approaches, and prognosis

Summary

Introduction

The purpose of stratified prevention and surveillance of primary liver cancer is to identify and eliminate the risk factors that promote the progression of chronic liver disease. The secondary prevention of HCC for the patients with chronic liver diseases focuses on surveillance, early diagnosis, and improving the cure rate and long-term survival.

Results

Conclusion