Abstract
Despite the use of standardized GPL and MPL units, significant inter-laboratory and inter-method variation in anticardiolipin antibody (aCL) testing still exists, limiting the clinical utility and inter-laboratory portability of test results. This article reviews published and unpublished guidelines (some developed using consensus procedures) that can be used to improve various aspects of: (1) specimen collection; (2) aCL assay manufacture and testing procedures; (3) quality control; and (4) interpretation (including reporting) of results; and in doing so, improve the consistency of aCL results between different laboratories, assays and runs. However, there is a still a need for consensus guidelines that combine and deal with all of the aforementioned aspects of aCL testing and reporting.
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