Abstract
Background and Aims: Discrimination of HRS type 1, associated with an ominous progno-sis from HRS type 2 and, moreover from normal renal function is of great clinical importance in patients with cirrhosis. The consensus definition (Hepatology 1996;23:164–176) of HRS type 1 comprises a serum creatinine concentration (Crea) above 2.5mg/100ml or a creatinine clearance (CrCl) below 20ml/min with cut-off values for normal renal function of 1.5mg/100ml or 40ml/min. Unfortunately, most studies on renal function in cirrhosis excluded pts. with HRS and the accordance of the cut-off values above has not been investigated. Aim of the present study was the comparison of Crea with measured CrCl and with the glomerular filtration rate calculated by the MDRD formula incorporating age, sex and race (GFRm), recently suggested to accurately reflect GFR (Clin Chem 2006;52:5–18).
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