Abstract
In a recent study we found no difference in the concentrations of luminal lactate in the rectum between nonsurvivors and survivors in early septic shock (<24 h). This study was initiated to investigate if there are any changes in the concentrations of luminal lactate in the rectum during the first 3 days of septic shock and possible differences between nonsurvivors and survivors. Methods. We studied 22 patients with septic shock in this observational study. Six to 24 h after the onset of septic shock the concentration of lactate in the rectal lumen was estimated by 4 h equilibrium dialysis (day 1). The rectal dialysis was repeated on day 2 and day 3. Results. The concentration of lactate in the rectal lumen did not change over the 3 days in neither nonsurvivors nor survivors. Rectal luminal and arterial lactate concentrations were not different. Conclusion. There was no change in the concentration of lactate in the rectal lumen over time in patients with septic shock. Also, there was no difference between nonsurvivors and survivors.
Highlights
In a recent study we found no difference in the concentrations of luminal lactate in the rectum between nonsurvivors and survivors in early septic shock (
Resuscitation of patients with septic shock is most often guided by only global parameters such as mean arterial pressure (MAP), central venous pressure (CVP), central venous oxygen saturation (ScvO2), and arterial lactate [1, 2]
Equilibrium dialysis is a simple, minimally invasive method for the estimation of the concentration of lactate luminally in the rectum and the method was first used to show differences in electrolyte transport and production of inflammatory markers in patients with inflammatory bowel disease [9,10,11]. Using this method in patients with severe sepsis and septic shock persisting for more than 24 h we have previously shown that luminal concentrations of lactate in the rectum correlate with large bowel permeability
Summary
Resuscitation of patients with septic shock is most often guided by only global parameters such as mean arterial pressure (MAP), central venous pressure (CVP), central venous oxygen saturation (ScvO2), and arterial lactate [1, 2]. Equilibrium dialysis is a simple, minimally invasive method for the estimation of the concentration of lactate luminally in the rectum and the method was first used to show differences in electrolyte transport and production of inflammatory markers in patients with inflammatory bowel disease [9,10,11]. Using this method in patients with severe sepsis and septic shock persisting for more than 24 h we have previously shown that luminal concentrations of lactate in the rectum correlate with large bowel permeability [12] and disease severity and outcome [13] indicating pathophysiological relevance. These observations suggested that the rectal lactate concentration could change over time in some patients and potentially be a marker of outcome
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
