Abstract
Deafness is the common reason which affects human health and causes human disability.It is caused by genetic and environmental factors. Hereditary hearing loss include the syndromic hearing loss and nonsyndromic hearing loss. In particular,the nonsyndromic hearing loss accounts for about 70%. Mutations in the GJB3 and mitochondrial 12SrRNA are associated with nonsyndromic hearing loss. This paper reports the correlation between GJB3 and mitochondrial 12SrRNA gene mutations with nonsyndromic hearing loss. To further clarify the correlation of the disease and the causes of a part of nonsyndromic hearing loss. To provide targeted genetic counseling and guidance for patients and their families, to offer evidence and strategies for prevention and treatment. Key words: Genes, Mitochondrial; Deafness; Mutation
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