Connectivity Guided Dimensions of Psychopathology in Youth

Abstract

Despite a vast body of literature, magnetic resonance imaging research has not yet delivered biomarkers for psychiatry. This is due, in part, to the high comorbidity of mental disorders, calling for a dimensional approach and the computational quantification of these dimensions in both clinical and imaging data. We use canonical correlation analysis (CCA) to investigate associations between anxiety, irritability, and disruptive behavior, three of the most common, impactful psychiatric problems in youth with each other and intrinsic brain connectivity.