Abstract
Summary and conclusionsThe dermal chemical response to atropine administration involved primarily losses of salt soluble, insoluble and total collagens and increased amounts of acid soluble collagen effecting the hexosamine content of the tissue. The increased dermal concentration of acid soluble collagen and the decreased dermal concentration of salt soluble collagen were maintained during the entire course of atropine administration, whereas the decreased concentration of both total and insoluble collagen was no longer significant by the last day of drug administration. To explain these changes in the dermal concentrations of the various collagens the possibility was suggested that atropine stimulated specifically the catabolism of insoluble collagen, and the changes in the dermal concentrations of the soluble collagens represented an anabolic response to this loss.
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