Connective tissue activation XXXIII. Biologically active cleavage products of CTAP-III from human platelets

C.W Castor,D.A Walz,C.G Ragsdale,P.A Hossler,E.M Smith,M.C Bignall,B.P Aaron,K Mountjoy

doi:10.1016/0006-291x(89)92330-9

Connective tissue activation XXXIII. Biologically active cleavage products of CTAP-III from human platelets

C.W Castor, D.A Walz + Show 6 more

https://doi.org/10.1016/0006-291x(89)92330-9

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Journal: Biochemical and biophysical research communications	Publication Date: Sep 1, 1989
Citations: 31

Affiliation: University of Michigan–Ann Arbor, Wayne State University

#Human Synovial Cell Cultures #Neutrophil Activating Properties + Show 8 more

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Abstract

Evidence for three new isoforms of CTAP-III from human platelets is presented; two NH2-terminal cleavage products were identified, CTAP-III (des 1-13) and CTAP-III (des 1-15). CTAP-III (des 1-13) has a pI of 8.6 and is a relatively stable proteolytic cleavage product that retains the capacity to stimulate [14C]GAG synthesis in human synovial cell cultures. CTAP-III (des 1-15) appears to be an elastase or chymotrypsin cleavage product and identical to NAP-2, an entity thought to have neutrophil activating properties.

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