Connection between markers of local and systemic inflammation in stable COPD

Abstract

It is considered that markers of local inflammation (including exhaled NO) represent the status of inflammation during COPD better then markers of systemic inflammation especially in stable phase. But there is not enough information what systemic biomarker is the most similar to them. <b>Aim:</b> to determine the significance of systemic biomarkers (C-reactive protein (CRP), fibrinogen, matrix metalloproteinase (MMP)-2, 9, hyaluronic acid (HA) in stable COPD in comparison with marker of local inflammation (exhaled NO). <b>Methods:</b> We determine exhaled NO level, plasma biomarkers in 15 patients with verified stable COPD (age – 60,4±0,94 years, men – 14 (93,3%), women – 1 (6,4%). We compared the level of plasma markers with control group (n=13), which are healthy person; level of exhaled NO – with fixed norm (less then 7 ppb). While measuring Spirman’s correlation level between exhaled NO and all other plasma makers we found the most representative parameter from systemic biomarkers. <b>Results:</b> are present in table 1. <b>Conclusions:</b> 1. Both local and systemic markers increase even in stable phase of COPD. 2. Only one plasma marker MMP-9 correlate with exhaled NO, and thus may be considered the most revealing one.