Abstract
One pathway to understanding the process by which enzymes catalyze chemical reactions is through the examination of internal correlated motions. There have been numerous studies that show these correlated motions may assist in catalysis, protein folding, and substrate specificity. It is also known through transition path sampling studies that rapid promoting vibrations contribute to enzyme catalysis. Human PNP is an important enzyme in purine metabolism, and it is the only purine salvage enzyme that catalyzes the reversible phosphorolysis of 6-oxopurine nucleosides to from a-D-ribose-1-phosphate.
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