Abstract
Connecting ncRNA Cigarette Smoking Studies with Tobacco Use Behaviors and Health Outcomes.
Highlights
Despite decreasing rates of smoking over the last several decades, maternal smoking during pregnancy (MSP) remains a major public health problem (Mathews, 2001)
As discussed by Maccani and Knopik, specific miRNAs were downregulated in placental cell lines exposed to nicotine and benzo[a]pyrene, but different miRNAs were dysregulated in lung and airway epithelium tissue
The few studies examining the effects of various aspects of cigarette smoking on miRNA expression have revealed that responses are likely to be highly complex, with tissue, temporal, and type of exposure leading to differential responses
Summary
Despite decreasing rates of smoking over the last several decades, maternal smoking during pregnancy (MSP) remains a major public health problem (Mathews, 2001). Animal studies provide more evidence that in utero exposure to nicotine directly affects offspring behaviors. As reviewed recently by Winzer-Serhan (2008), other animal studies examining the effects of nicotine, which does not contain all of the ingredients in tobacco, have been contradictory.
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