Abstract
Cell migration is essential to many physiological and pathological processes such as embryogenesis, wound healing or metastasis. This complex process involves a tight coordination between three essential steps – protrusion, adhesion and retraction. Although historically protrusion and adhesion have been linked through structural protein–protein interactions, a direct functional link between the two has long eluded biologists. Recent work from the Burridge laboratory now suggests that vinculin, a cytoskeletal protein involved in the building of the adhesion scaffold, could be the missing link that connects early adhesion sites to the actin-driven protrusive machinery.
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