Connected speech deficit as an early hallmark of CSF-defined Alzheimer's disease and correlation with cerebral hypoperfusion pattern

Abstract

There is still a growing interest for the detection of early and non-invasive biomarkers for diagnosis of prodromal Alzheimer's disease (AD). Although progressive episodic memory impairment is the typical predominant feature of AD, communicative difficulties can be already present at the early stages of the disease and could represent an early non-invasive AD biomarker. This study investigate narrative discourse production deficit as a hallmark of cerebrospinal fluid (CSF) defined prodromal AD and its correlation with cerebral hypoperfusion pattern.