Connectable DNA-logic operation using droplets and rupture/reformation of bilayer lipid membranes

Kosuke Inoue ,Toshihisa Osaki ,Masahiro Takinoue ,Hiroki Yasuga ,Norihisa Miki ,Kanichi Kamiya ,Ryuji Kawano ,Shoji Takeuchi

doi:10.1109/transducers.2015.7181029

Connectable DNA-logic operation using droplets and rupture/reformation of bilayer lipid membranes

Kosuke Inoue , Toshihisa Osaki + Show 6 more

https://doi.org/10.1109/transducers.2015.7181029

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Publication Date: Jun 1, 2015

Citations: 5

Affiliation: Keio University, Kanagawa Academy of Science and Technology, Tokyo Institute of Technology, Tokyo University of Agriculture and Technology

#Membrane Protein's Channel #NOR Operation + Show 8 more

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Abstract

This paper experimentally demonstrated the connection of logic gates using DNA and membrane protein's channel reconstituted into bilayer lipid membranes (BLMs). In this system, droplets worked as the carrier of DNA to convey it as biological signal to next stage and reformation and rupture of BLM accelerated DNA transfer between droplets. Furthermore, DNA is detected based on the electrical and physical characters of DNA translocation via membrane protein's channel. In this study, we successfully demonstrated NOR operation by connecting OR and NOT gate. This system is readily applicable to develop high sensitive biosensor and computing system imitating biological information processing.

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