Abstract
BackgroundTo determine the effect of various factors to the preservation rate of the conjunctival layer borderlines of glaucomatous eyes treated with anti-glaucoma eye drops.MethodsAnterior segment optical coherence tomography (AS-OCT) images of the bulbar conjunctiva of 328 eyes were analyzed with and without anti-glaucoma eye drops to quantify the preservation rates of the conjunctival layer borderlines.ResultsMore anti-glaucoma eye drops and a longer duration of administration were associated with lower preservation rates of the borderlines between both the conjunctival stroma/Tenon’s capsule (P < 0.001 and P < 0.001, respectively) and Tenon’s capsule/sclera (P < 0.001 and P < 0.001, respectively). Prostaglandin analogs and fixed combinations of β-blockers/prostaglandin analogs were prognostic factors for lower preservation rates of the borderlines between both the conjunctival stroma/Tenon’s capsule (P < 0.001 and P = 0.009, respectively) and Tenon’s capsule/sclera (P < 0.001 and P = 0.008, respectively).ConclusionsNumerous anti-glaucoma eye drops and their long-term administration are associated with the disruption of the bulbar conjunctival borderlines detected by AS-OCT.
Highlights
To determine the effect of various factors to the preservation rate of the conjunctival layer borderlines of glaucomatous eyes treated with anti-glaucoma eye drops
Most anti-glaucoma eye drops do not cause severe systemic effects, some studies have demonstrated that long-term administration of anti-glaucoma eye drops induces histopathological and inflammatory changes in the conjunctival tissues
We previously demonstrated that Anterior segment optical coherence tomography (ASOCT) images can detect conjunctival inflammatory responses and subconjunctival scarring after phacoemulsification and pars plana vitrectomy [14, 15]
Summary
To determine the effect of various factors to the preservation rate of the conjunctival layer borderlines of glaucomatous eyes treated with anti-glaucoma eye drops. Most anti-glaucoma eye drops do not cause severe systemic effects, some studies have demonstrated that long-term administration of anti-glaucoma eye drops induces histopathological and inflammatory changes in the conjunctival tissues. These changes are deleterious because altered histology of conjunctival tissue was shown to be a risk factor for surgical failure in patients who underwent trabeculectomy [4,5,6,7,8,9,10,11,12]
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