Conjunctival melanoma in patients with xeroderma pigmentosum: a series of four cases.

Abstract

To study the demographic features, treatment, histopathology, and outcomes in patients of xeroderma pigmentosum (XP) with conjunctival melanoma. Retrospective case series. The median age at presentation was 18years (range 9-30years). There were three females and one male patient presenting with a median duration of symptoms of 3months (range 1-60months). The tumor was located in the bulbar conjunctiva in all 4 patients. All patients had corneal involvement by the tumor. The median tumor basal diameter was 7mm (range 4-15mm). Wide tumor excisional biopsy with alcohol keratoepithelectomy, cryotherapy to the free margins, and amniotic membrane grafting was done in three patients. One patient underwent orbital exenteration for extensive tumor. One patient also received adjuvant plaque brachytherapy for microscopic residual tumor. Over a median follow-up of 22months (range 2-101months), there were no recurrences, metastasis, or death. Conjunctival melanoma in XP is rare and manifests at a younger age.