Conjunctival Lesions; a Histopathologic Review in Fars Province, Iran.

Roshanak Aliakbar-Navahi,Samaneh Koohestani,Elham Abedi,Nosaibe Seirfar,Mohammadjavad Ashraf

doi:10.4103/2008-322x.163774

Abstract

Purpose:To determine the prevalence of various types of conjunctival lesions, at a tertiary ophthalmic center in Fars Province, South of Iran.Methods:Histopathologic slides and medical records of conjunctival lesions submitted to the pathology department of Khalili Hospital, Shiraz, Iran were reviewed from April, 2009 to July, 2013. The histopathologic diagnoses were categorized into benign, pre-malignant, and malignant lesions. The prevalence of various types of conjunctival lesions was calculated.Results:Histologic sections of 631 conjunctival lesions were reviewed. Benign lesions were most prevalent (81.8%), followed by premalignant (10.8%) and malignant (7.4%) lesions. Pterygia were the most common benign lesions (69.2%), intraepithelial dysplasia constituted most cases of premalignant lesions (94.1%), and squamous cell carcinoma was the most frequent malignant lesion (93.6%). Benign lesions were the most common type of lesions in all age groups, however the prevalence of malignant lesions increased significantly with age (P < 0.001).Conclusion:Benign lesions were the most common conjunctival lesions with pterygia on top of the list, while intraepithelial neoplasia and squamous cell carcinoma were the most common premalignant and malignant lesions, respectively. Conjunctival malignant lesions were more prevalent with older age.

Highlights

IntroductionConjunctival tumors, based on their origin, are categorized into melanocytic and non‐melanocytic types, both arising from epithelial and stromal components.[2] Conjunctival epithelial lesions vary from benign tumors such as papillomas, to malignant lesions such as squamous cell carcinoma (SCC).[3] Melanocytic and non‐melanocytic tumors have been reported to comprise 53 and 47% of all excised conjunctival tumors, respectively.[2]
The conjunctiva is readily visible and partially exposed to sunlight; conjunctival tumors and related lesions are recognizable early in their course.[1]Received: 15‐01‐2014Accepted: 17‐06‐2014Access this article onlineQuick Response Code: Website: www.jovr.orgConjunctival tumors, based on their origin, are categorized into melanocytic and non‐melanocytic types, both arising from epithelial and stromal components.[2]
The histologic diagnoses were categorized into three groups of benign, premalignant and malignant lesions according to the World Health Organization (WHO) classification of conjunctival tumors.[10]

Summary

Introduction

Conjunctival tumors, based on their origin, are categorized into melanocytic and non‐melanocytic types, both arising from epithelial and stromal components.[2] Conjunctival epithelial lesions vary from benign tumors such as papillomas, to malignant lesions such as squamous cell carcinoma (SCC).[3] Melanocytic and non‐melanocytic tumors have been reported to comprise 53 and 47% of all excised conjunctival tumors, respectively.[2]. Ocular surface squamous neoplasia (OSSN) are composed of epithelial lesions such as dysplasia, carcinoma in situ and SCC which involve the conjunctiva.

Methods

Results

Conclusion