Abstract
Introduction Cryoglobulins are groups of cold-precipitable proteins greatly resembling normal γ-globulin,1and their most striking characteristic is their ability to precipitate when exposed to a lowered temperature. An essential part of the phenomenon relates to the precipitate returning to solution when the temperature is raised to 37 C. The most prominent symptom noted in this disease is a particular sensitivity to lowered temperature with oronasal bleeding a common finding.2Physical findings include weight loss, pallor, petechiae with purpura, mottling and occasional ulceration of the lower extremity. The ocular findings include slowing and stasis of blood flow with marked erythrocytic aggregations in the vessels of the bulbar conjunctiva.3Ophthalmoscopic study has demonstrated dilated retinal veins with slowing and segmentation as well as occasional retinal hemorrhages and exudates.4 In 1957 Harders5reported observations on conjunctival blood flow in a patient with Waldenstrom's macroglobulinemia who in addition
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