Abstract
Conjunctival nevi, conjunctival primary acquired melanosis (PAM), and conjunctival melanomas all arise from melanocytes that migrate from the neural crest to reside in the conjunctival epithelium. Conjunctival melanoma may arise de novo or from preexisting conjunctival nevus or PAM. In the medical literature, conjunctival melanoma is sometimes labeled together with uveal melanoma as “ocular melanoma.” The clinical behavior, molecular biology, and the histopathologic features of conjunctival and uveal melanoma are clearly different; therefore, conjunctival melanoma should be approached as an entity separate from uveal melanoma.
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