Abstract
AbstractTetracycline (TecH2) reacts with triphenylantimony (TPSbiii) in the presence of hydrogen peroxide to form the [Ph3Sbv(Tec)] (TecAn). The sodium penicillin G (PenH) conjugates with Ag(i) towards [Ag(Pen)(MeCN)]2(PenAcAg).TecAnandPenAcAgwere characterized by melting point, X-ray fluorescence spectroscopy, attenuated total reflectance-Fourier transform infra-red, thermogravimetric-differential thermal analysis in solid state, ultraviolet-Vis spectroscopy, and nuclear magnetic resonance (1H and13C-NMR), spectroscopies in solution. The molecular weight was determined with cryoscopy. Thein vitrocytotoxic activity ofTecAnandPenAcAgwas evaluated against the human breast adenocarcinoma cell lines: MCF-7 (positive to hormones receptor (HR+)), MDA-MB-231 (negative to hormones receptor (HR−)), and theirin vitrotoxicity and genotoxicity were tested against normal human fetal lung fibroblast cells (MRC-5). The MCF-7 cells’ morphology and acridine orange/ethidium bromide staining suggest an apoptotic pathway for cell death. The binding affinity ofTecAnandPenAcAgwith DNA was, ex vivo, studied by UV-Vis and fluorescence spectroscopy and viscosity measurements of DNA solution.PenAcAginhibits lipoxygenase (LOX) stronger than cisplatin, while no inhibitory activity has been detected forTecAn. The reduction of non-active Sb(v), ofTecAn, to active Sb(iii) by glutathione (a tripeptide over expressed in tumor cells) was also investigated.
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