Abstract
We show that hydrogen titanate(H2Ti3O7) nanotubes form strongly associated reversible nano-bio-conjugates with the vitalrespiratory protein, cytochrome c. Resonance Raman spectroscopy along with directelectrochemical studies indicate that in this nano-bio-conjugate, cytochrome c exists in anequilibrium of two conformational states with distinctly different formal redoxpotentials and coordination geometries of the heme center. The nanotube-conjugatedcytochrome c also showed enhanced peroxidase activity similar to the membrane-boundprotein that is believed to be an apoptosis initiator. This suggests that such ananotube–cytochrome c conjugate may be a good candidate for cancer therapy applications.
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