Abstract
Use of light for selective and spatio-temporally resolved control of cell functions is emerging as a valuable alternative to standard electrical and chemical methods. We propose the use of organic semiconductors as biocompatible optical transducers, and we focus in particular on breakthrough applications in regenerative medicine. Devices able to selectively and precisely modulate the fate of living cells upon visible light will be critically discussed. Examples include optical modulation of the activity of both excitable and non-excitable cells, control of essential cellular switches like transient receptor potential channels and other cationic channels, as well as effective modulation of intracellular calcium signalling for precise control of cell metabolic processes.
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