Conjugated hydrophobic and hydrophilic blocks through a drug moiety as a leading macromolecular system for sustainable drug delivery

Abstract

Ring-opening polymerization (ROP) of e-caprolactone (CL) had been performed at 160 °C in the presence of drug molecules such as penicillin g (Pen), streptavidin (Strep) and terramicin (Ter) as a lone chemical initiator using the catalyst, stannous octoate (SO) under N2 atmosphere. The prepared drug bridged poly (e-caprolactone) (PCL) was further copolymerized with tetrahydrofuran (THF) and the diblock copolymers were examined using the various analytical tools (FT-IR, DSC, TGA, SEM, FE-SEM, EDX, UV-visible and GPC). The functionalities of the drug bridged diblock copolymers were concluded by FT-IR spectra. The formation of the diblock copolymer was further understood from the increase in Mw. The drug release activity of homo and diblock copolymer had been tested with the drug release model and mechanism. The mechanical properties are also studied.