Abstract
Aim: To test the antimicrobial effect of carbon monoxide-releasing molecules (CORMs) conjugated with azoles on different microorganisms. Methods & results: We used broth microdilution, checkerboard and cytotoxicity assays, as well asimaging, fluorescenceand bioluminescence experiments to study [Re(CO)3(2,2'-bipyridyl)(Ctz)]+ (also known asReBpyCtz). ReBpyCtz exhibits alow minimum inhibitory concentrationvalue, increases the intracellular formation of reactive oxygen species and causes significant alterations on Staphylococcus aureus's membrane. ReBpyCtz is active against fungi, having a more prolonged fungicidal effect on Candida glabrata than clotrimazole andis selectively active onblood-stage malaria parasites, at a concentration that is not toxicto kidney epithelial cells. Conclusion: Conjugated CORMs have the potential to be active against different types of pathogens, thus constituting a promising class of broad-spectrum antimicrobials.
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