Abstract
Background: Efficiency of both photodynamic and boron-neutron capture anticancer therapies (BNCT) depends on the properties of the used photo-and neutronsensitizer. We report on the synthesis and properties of the advanced photo-and neutronsensitizer designed as a conjugate of chlorin e6 with iron bis(dicarbollide) nanocluster. Results: The conjugate is shown to accumulate efficiently in rat glioblastoma C6 cells delivering >109 boron atoms per cell and thus meeting requirements for BNCT agents, to provide photoinduced 50% death of C6 cells at 35±3nM, to be not toxic for cells without activating stimulus. Conclusions: The conjugate is aprospective theranostic agent for photodynamic, BNCT and fluorescent diagnostics of tumors.
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