Abstract
Temperature affects both the stability of nucleic acid detectors and efficiency of DNA amplification. In this study, temperature and flow inside a nucleic acid detector were simulated and the results were used to design vents for the instrument casing. A test platform was constructed to collect experimental temperature data that were used for simulation validation. The experimental and simulation results showed that the temperature error was less than ±3 K. A total of two heat-dissipation schemes were designed based on the simulation and a new instrument casing was fabricated based on the scheme with the best results. Nucleic acid amplification was performed continuously for 120 min using a prototype with the new casing. The temperatures of the monitoring points were stable and the maximum temperature measured only 307.76 K (34.61 °C). Therefore, waste heat was effectively eliminated, which ensured safety of the electronic components and stability of the nucleic acid detection process.
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