Abstract
Conjugate eye deviation (CED) is generally attributed to a lesion of the frontal eye fields or its subcortical projections leading to a contralateral saccadic palsy. This theory is mainly based on experimental studies. However, clinical studies yield rather conflicting results as to the localizing value of this sign. The authors therefore performed a prospective study of 74 patients with CED caused by a hemispheric lesion. The diagnosis and site of the lesion was based on CT-scan and/or autopsy findings. In all but two patients the sign was caused by a stroke. The results of the study can be summarized as follows1. The area of the frontal eye fields is not damaged in most patients with CED, rather, the inferior parietal lobule is involved.2. One exclusive location of the lesion responsible for CED is unlikely.3. CED can probably result from a lesion at different sites within the circuit formed by inferior parietal lobule-frontal eye fields-superior colliculus and pontine reticular formation, predominantly...
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