Abstract
4-Substituted-butenolides treated with free hydroxylamine at pH=5 undergo conjugate addition - rearrangement to afford isoxazolidin-5-ones. This is in contrast to N-substituted hydroxylamines which under the same conditions produce Michael adducts only. In the presence of base, butenolides undergo racemization via flat tautomeric forms.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have