Abstract
While the stereoselective conjugate addition of various nucleophiles to α,β-unsaturated substrates has been utilized for a large number of chiral catalyzed systems, the use of lithium enolates derived from ketones or esters has been sparsely demonstrated. The authors describe the addition of unstabilized lithium enolates to a α,β-unsaturated ester in high yield and moderate enantioselectivity.
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