Abstract
ABSTRACTSuperoxide dismutase in relation to Alzheimer's disease can be thought as the basis for the development of copper coordination complexes designed as radiopharmaceuticals to assist in the diagnosis/treatment of this disorder. In such a fascination, a systematic study of a series of three Cu(II)-N-dehydroacetic acid-salicylic acid hydrazide (H2dha-shz) Schiff base complexes, based on hyphenated experimental and theoretical approach, having the general composition formula as [Cu(dha-sahz)(L)], where L is H2O, imidazole (imdH)] or benzimidazole (bimdH) is presented. Theoretical calculations have been performed for one of the representative complexes containing imidazole as a co-ligand. B3LYP/LANL2DZ combination was used to carry out the required calculations. From the study, a suitable square planar geometry has been found for the complexes under investigation. In addition to the density functional theory (DFT)-experimental formulation of target metallic systems, superoxide dismutation and electroacti...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
