Abstract
A child with the congenital rubella syndrome and immunoglobulin abnormalitiescharacterized by a tremendous increase in IgM, delayed appearance of IgG, and absence of IgA, is described. “Rheumatoid factor” and cold agglutinins were present. Treatment with an antiviral agent, l-adamantanamine, was thought to result in clinical improvement. An unusual feature of the case was the late development of retinitis and cataracts. A child with the congenital rubella syndrome and immunoglobulin abnormalitiescharacterized by a tremendous increase in IgM, delayed appearance of IgG, and absence of IgA, is described. “Rheumatoid factor” and cold agglutinins were present. Treatment with an antiviral agent, l-adamantanamine, was thought to result in clinical improvement. An unusual feature of the case was the late development of retinitis and cataracts.
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