Abstract
MRI evaluations of pituitary volume, and clinical and endocrine findings in 101 pituitary dwarfs with congenital idiopathic growth hormone deficiency (CIGHD) are reported from the Departments of Neuroradiology and Pediatrics, Scientific Institute H San Raffaele, Milan, Italy.
Highlights
MRI evaluations of pituitary volume, and clinical and endocrine findings in 101 pituitary dwarfs with congenital idiopathic growth hormone deficiency (CIGHD) are reported from the Departments of Neuroradiology and Pediatrics, Scientific Institute H San Raffaele, Milan, Italy
A congenital defect involving the pituitary and hypothalamus would account for the MRI abnormalities and the clinico-endocrinological features of CIGHD patients
Breech delivery is the result of the midline brain anomaly, rather than the cause
Summary
MRI evaluations of pituitary volume, and clinical and endocrine findings in 101 pituitary dwarfs with congenital idiopathic growth hormone deficiency (CIGHD) are reported from the Departments of Neuroradiology and Pediatrics, Scientific Institute H San Raffaele, Milan, Italy. Ectopia of the posterior pituitary (PPE) was discovered in 59 patients and pituitary volume was reduced. Breech delivery, and other congenital brain anomalies occurred more frequently in PPE patients than in the 42 with normal posterior pituitary except for a narrowed stalk. Associated anomalies included septo-optic dysplasia, with septum pellucidum agenesis and/or hypoplastic optic chiasm, corpus callosum dysgenesis, and basilar impression.
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