Abstract
ABSTRACT The effect of 8-azaguanine on the development of offspring of mice was investigated by injecting mothers once intraperitoneally with 0·08 to 0·4 mg. / g. of body-weight on a day between the 7th and 15th of gestation. The principal teratogenic effect was on the skeletal system. Among the malformations found were cleft palates and various abnormalities of the extremities; abnormally directed digits due to deviation of interphalangeal joints were most frequently encountered. When administered between the 7th and 14th days of gestation, this compound is frequently lethal to embryos, causing death immediately or a few days after injection.
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