Abstract
ABSTRACT Congenial hypothyroidism (CH) is a common endocrine disorder in newborns; if left untreated, it can lead to mental subnormality. CH has also been known to affect renal development and physiology. However, there are only few case reports on the association between CH and nephrocalcinosis. We report a case of a 9-month-old female child who presented with gross clinical features of CH such as growth delay, delayed motor milestones, macroglossia, stridor, protruded abdomen, umbilical hernia, and cradle cap skull. Investigations revealed primary hypothyroidism, renal dysfunction, metabolic acidosis with normokalemia, and acidic urine and bilateral medullary nephrocalcinosis. After initiation of levothyroxine, improvement in renal functions and metabolic acidosis was observed, indicating the direct role of thyroid hormones in regulating renal physiology. Presence of nephrocalcinosis and renal dysfunction should be looked upon in any case of untreated CH. High doses of calcium and cholecalciferol supplementation must be avoided as it may lead to hypercalciuria, leading to development or deterioration of nephrocalcinosis and renal dysfunction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
