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Abstract
The human immunodeficiency virus (HIV) type 1 is highly neurotropic, entering the central nervous system compartment within the first few weeks of systemic infection and may cause a spectrum of neurological complications collectively known as neuroAIDS. In children infected through vertical transmission, the neurological manifestations may display a more complex phenotype as a consequence of the effects of HIV on the immature brain and contribute significantly to the morbidity of HIV infection. With the early initiation of combination antiretroviral therapy, there has been an improvement in the overall health of children with vertically transmitted HIV infection. HIV encephalopathy (HIVE) which previously presented with severe neurodisability and demise, now presents with a more insidious phenotype in association with prolonged survival. As these children survive into adolescence and adulthood, behavioural and psychiatric complications are becoming more relevant in clinical practice. This talk provides a general overview of neuroAIDS from congenital transmission in childhood and adolescence.
Published Version
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