Congenital Generalized Fibromatosis

Abstract

Congenital generalized fibromatosis is an uncommon condition that most commonly affects the male newborn or young infant. There is widespread osseous lytic lesions. These lesions most commonly involve metaphyseal regions of long bones and may be expanded with or without a sclerotic margin. There can be involvement of the skin, muscles, viscera, and subcutaneous tissue. Single or multiple bone lesions and soft-tissue tumors may occur in the Infant, and this entity is second only to angiomatous lesions as the most common neoplasms in this age group. The authors illustrate a case of congenital generalized fibromatosis in an infant with hepatic involvement demonstrated on a radionuclide bone scan. A computed tomographic study demonstrates the lesion, which was confirmed with biopsy.