Abstract
Onychomycosis represents 40% of all nail disorders. It is commonly observed in adults but rarely in children. Candida species, although frequently isolated in many occasions, are rarely proved to be the causative agent in the disease. Here we present a male infant who presented with congenital candidal onychomycosis since 1 week of age. He was born to a 33-year-old healthy woman (gravida 2 para 2) via normal vaginal delivery at 36th week of gestation. Before childbirth, the mother had a history of vaginal discharge, from which the bacterial culture showed yeast-like microorganism in moderate amount. On examination, the neonate had no evidence of mucosal and cutaneous candidiasis except yellowish discoloration and thickening of the fingernails and toenails with inflammation of the periungual area. The KOH preparation from nails revealed a large number of pseudohyphae. The fungal culture revealed the presence of Candida albicans. Histopathologically, the nail clipping showed numerous PAS-positive hyphal elements. In addition, ribosomal internal transcribed spacer (ITS) amplified by PCR from nail clippings hybridized only with Candida albicans-specific oligonucleotide probe immobilized on a DNA chip which contained an array of oligonucleotides of detection of yeasts and dermatophytes. The patient received topical sulconazole nitrate 1% solution for 2 months, which led to cure of infected fingernails.
Paper version not known (
Free)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
