Abstract

Plasma levels of aldosterone(PA) and 17hydroxyprogesterone(17-OHP), urinary pregnanetriol (PT), pregnanetriolone and 17-ketosteroids were determined in 19 children with CAH. 17-OHP in 5 cases before onset of therapy was at least 40 times above normal range, PA also being elevated. Well controlled patients had normal PA and 17-OHP below 5 ng/ml. Both steroids were well stimulable by ACTH. In 3 poorly controlled cases elevated PT and 17-OHP up to 131 ng/ml were found, Withdrawal of therapy resulted in pronounced rise in PA and 17-OHP. Additional exogeneous ACTH had no effect in 7 cases leading to further stimulation in the other children. Correlation between 17-OHP and PT was excellent (r=0,84, p<0,003) and fairly good between PA and 17-OHP (r=0,65, p<0,01). The data confirm the value of 17-OHP determinations for diagnosis and management of CAH on the one hand, and the compensatory elevated aldosterone production on the other.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.