Abstract
Neonatal leukaemia is a rare blood cancer occurring in baby less than 30 days of life is characterized by proliferation of white cells without known and obvious reasons. We report a case of a 7-day- old girl diagnosed with congenital leukaemia. At the time of presentation, she was evaluated as early neonatal sepsis. However, her laboratory investigations were consistent with B cell acute lymphoblastic leukaemia. Her cytogenetic analysis showed 46 XX trisomy 22, t(5,15) (p15,q15) and del 7 (q33,q35). She was managed with standard Interfant 06 protocol and had achieved marrow remission during the course of chemotherapy. Our case highlights the differentiation between lymphocytic leukemoid reaction and lymphoblastic malignant cells and also congenital acute lymphoblastic leukaemia who had a good outcome from the chemotherapy.
Highlights
Leukaemia among neonates is a rare disease and to make it unusual, congenital leukaemia usually associated with syndromic child or other anomalies
Non-DS neonatal leukaemia is a very rare disease and it has to be differentiated with lymphocytic leukemoid reaction which is commonly associated with infection
Congenital leukaemia is a diagnosis made at first month of life and it is a rare disease
Summary
Leukaemia among neonates is a rare disease and to make it unusual, congenital leukaemia usually associated with syndromic child or other anomalies. Diagnosis of neonatal leukaemia is made in newborn presenting less than 30 days of life. Non-DS neonatal leukaemia is a very rare disease and it has to be differentiated with lymphocytic leukemoid reaction which is commonly associated with infection. Malaysian Journal of Paediatrics and Child Health (MJPCH) | (Early online – December 2021) | Page 47 of 50 newborn.
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